Tumor hypoxia and metabolism
Dr Milica VUCETIC
Chargée de Recherche - Équipe Cellules Souches et Tumeurs du CerveauTel. +377 97 77 44 21
Email : [javascript protected email address]
CV
Thèmes de recherche développés
- Signalisation d'hypoxie dans les cancers
- Cibles métaboliques dans le traitement du cancer
- Rôle de l'hypoxie dans la reprogrammation métabolique
- Interaction HIF-1 / AMPK dans la plasticité phénotypique
Publications CSM
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Exploiting Integrin-αVβ3 to Enhance Radiotherapy Efficacy in Medulloblastoma via Ferroptosis
Gotorbe C, Segui F, Echavidre W, Durivault J, Blanchard T, Vial V, Pagnuzzi-Boncompagni M, Villeneuve R, Amblard R, Garnier N, Ortholan C, Serrano B, Picco V, Pouyssegur J, Vucetic M, Montemagno C
Curr. Oncol. 31, 7390–7402 -
'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives
Pouyssegur J, Marchiq I, Parks S K, Durivault J, Zdralevic M, Vucetic M
Semin Cancer Biol Vol.86, Part 2, pp. 334-346 -
Genetic Disruption of the γ-Glutamylcysteine Ligase in PDAC Cells Induces Ferroptosis-Independent Cell Death In Vitro without Affecting In Vivo Tumor Growth
Daher B, Meira W, Durivault J, Gotorbe C, Pouyssegur J, Vucetic M
Cancers 14, 3154 -
Involvement of Ferroptosis in Diabetes-Induced Liver Pathology
Stancic A, Velickovic K, Markelic M, Grigorov I, Saksida T, Savic N, Vucetic M, , Martinovic V, Ivanovic A, Otasevic A
Int J Mol Sci 23(16):9309 -
Metabolic Rewiring toward Oxidative Phosphorylation Disrupts Intrinsic Resistance to Ferroptosis of the Colon Adenocarcinoma Cells
Gotorbe C, Durivault J, Meira W, Cassim S, Zdralevic M, Pouyssegur J, Vucetic M
Antiox 11(12), 2412 -
A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT(KO) Pancreatic Ductal Adenocarcinoma Cells
Meira W, Daher B, Parks S, Cormerais Y, Durivault J, Tambutté E, Pouyssegur J, Vucetic M
Cancers 13(1434) -
Amino acid transporters are a vital focal point in the control of mTORC1 signaling and cancer
Cormerais Y, Vucetic M, Parks S, Pouyssegur J
Int J Mol Sci 22,23 -
Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria
Otasevic V, Vucetic M, Grigorov I, Martinovic V, Stancic A
Oxidative Medicine and Cellular Longevity 2021(5537330) -
Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors
Vucetic M, Daher B, Cassim S, Parks S, Pouyssegur J
In Ferroptosis: Mechanism and Diseases, Advances in Experimental Medicine and Biology A. F. Florez, H. Alborzinia (eds.), 1301: 7-24 -
Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death
Daher B, Vucetic M, Pouyssegur J
Front Oncol 10: 723 -
Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis
Vucetic M, Daher B, Cassim S, Meira W, Pouyssegur J
Cell Death Dis 11, 789: 1-13 -
Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer
Cassim S, Vucetic M, Zdralevic M, Pouyssegur J
Cancers 12(5): 1119 -
Genetic ablation of the cystine importer xCT induces ferroptosis in pancreatic ductal adenocarcinoma cells
Vucetic M, Daher B, Durivault J, Pouyssegur J
Free Radic Biol Med. 139(Suppl. 1): S55 -
Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
Daher B, Parks S, Durivault J, Cormerais Y, Baidarjad H, Tambutté E, Pouyssegur J, Vucetic M
Cancer Res 79(15):3877-3890 -
Targeting amino acids transporters (SLCs) to starve cancer cells to death
Cormerais Y, Vucetic M, Pouyssegur J
Biochem Biophys Res Commun 520: 691-693 -
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Cormerais Y, Massard P-A, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe M F, Parks S, Pouyssegur J
J Biol Chem 293(8): 2877-2887 -
Disrupting glucose-6-phosphate isomerase fully suppresses the ‘Warburg effect’ and activates OXPHOS with minimal impact on tumor growth except in hypoxia
Cunha de Padua M, Delodi G, Vucetic M, Durivault J, Vial V, Bayer P, Noleto G, Mazure N, Zdralevic M, Pouyssegur J
Oncotarget 8(50): 87623-87637 -
Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death.
Zdralevic M, Vucetic M, Daher B, Marchiq I, Parks S, Pouyssegur J
Adv Biol Regul pii: S2212-4926(17): 30189-30196 -
The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code
Vucetic M, Cormerais Y, Parks S, Pouyssegur J
Front Oncol 7(319): 1-15