Scientific Directory
Dr Scott PARKS
Chercheur Post-Doctorant - Équipe Hypoxie Tumorale et MétabolismeTel. +377 97 77 44 07
Email : [javascript protected email address]
CV
Thèmes de recherche développés
Le rôle des protéines régulatrices du pH et leurs interactions avec le métabolisme dans la progression des cellules tumorales.
Publications CSM
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A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT(KO) Pancreatic Ductal Adenocarcinoma Cells
Meira W, Daher B, Parks S, Cormerais Y, Durivault J, Tambutté E, Pouyssegur J, Vucetic M
Cancers 13(1434) -
Amino acid transporters are a vital focal point in the control of mTORC1 signaling and cancer
Cormerais Y, Vucetic M, Parks S, Pouyssegur J
Int J Mol Sci 22,23 -
Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors
Vucetic M, Daher B, Cassim S, Parks S, Pouyssegur J
In Ferroptosis: Mechanism and Diseases, Advances in Experimental Medicine and Biology A. F. Florez, H. Alborzinia (eds.), 1301: 7-24 -
Lactate and acidity in the cancer microenvironment
Parks S, Mueller-Klieser W, Pouyssegur J
Annu Rev Cancer Biol 4: 141-158 -
Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells
Guerrini G, Durivault J, Filippi I, Criscuoli M, Monaci S, Pouyssegur J, Naldini A, Carraro F, Parks S
Biochem Biophys Res Commun 516(2):408-413 -
Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
Daher B, Parks S, Durivault J, Cormerais Y, Baidarjad H, Tambutté E, Pouyssegur J, Vucetic M
Cancer Res 79(15):3877-3890 -
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity
Brolih S, Parks S, Vial V, Durivault J, Mostosi L, Pouyssegur J, Pagès G, Picco V
BMC Cancer 18(1): 249 -
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Cormerais Y, Massard P-A, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe M F, Parks S, Pouyssegur J
J Biol Chem 293(8): 2877-2887 -
Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death.
Zdralevic M, Vucetic M, Daher B, Marchiq I, Parks S, Pouyssegur J
Adv Biol Regul pii: S2212-4926(17): 30189-30196 -
Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells
Parks S, Cormerais Y, Durivault J, Pouyssegur J
Oncotarget 8(6): 10225-10237 -
Hypoxia and cellular metabolism in tumour pathophysiology
Parks S, Cormerais Y, Pouyssegur J
J Phycol 595(8): 2439-2450 -
Metabolic Plasiticy in Cancers-Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs
Zdralevic M, Marchiq I, de Padua M M C, Parks S, Pouyssegur J
Front Oncol 7: 313 -
Targeting pH regulating proteins for cancer therapy-Progress and limitations
Parks S, Pouyssegur J
Semin Cancer Biol 43: 66-73 -
The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code
Vucetic M, Cormerais Y, Parks S, Pouyssegur J
Front Oncol 7(319): 1-15 -
Genetic disruption of the multifunctional CD98/LAT1 complex demonstrates the key role of essential amino acid transport in the control of mTORC1 and tumor growth
Cormerais Y, Giuliano S, Le Floch R, Front B, Durivault J, Tambutté E, Massar P-A, Rodriguez de la Ballina L, Endou H, Wempe M F, Palacin M, Parks S, Pouyssegur J
Cancer Res 76(15): 4481-4492 -
Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export
Parks S, Cormerais Y, Marchiq I, Pouyssegur J
Mol Aspects Med 47-48: 3-14 -
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
Pettersen E O, Ebbesen P, Gieling R G, Williams K J, Dubois L, Lambin P, Ward C, Meehan J, Kunkler I H, Langdon S P, Ree A H, Flatmark K, Lyng H, Calzada M J, Peso L D, Landazuri M O, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton D C, Haider S, Buffa F M, Harris A L, Scozzafava A, Supuran C T, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop K M, Wouters B G, Koritzinsky M, Mujcic H, Cojocari D
J Enzyme Inhib Med Chem 30(5): 689-721 -
The Na+/HCO3- Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells
Parks S, Pouyssegur J
J Cell Physiol 230(8): 1954-1963 -
Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome
Doyen J, Trastour C, Ettore F, Peyrottes I, Toussant N, Gal J, Ilc K, Roux D, Parks S, Ferrero J M, Pouyssegur J
Biochem Biophys Res Commun 451(1): 54-61 -
Disrupting proton dynamics and energy metabolism for cancer therapy
Parks S, Chiche J, Pouyssegur J
Nat Rev Cancer 13(9): 611-623 -
Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels
Parks S, Mazure N M, Counillon L, Pouyssegur J
J Cell Physiol 228(9): 1854-1862 -
Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis
Doyen J, Parks S, Marcie S, Pouyssegur J, Chiche J
Front Oncol 2: 199