Scientific Directory
Dr Luis GARCIA
Co-Directeur LIA-BAHNTel. +33 1 70 42 94 16
Email : [javascript protected email address]
Thèmes de recherche développés
Publications CSM
-
Dystrophin myonuclear domain restoration governs treatment efficacy in dystrophic muscle
Morin A, Stantzou A, Petrova O N, Hildyard J, Tensorer T, Matouk M, Petkova M V, Richard I, Manoliu T, Goyenvalle A, Falcone S, Schuelke M, Laplace-Builhé C, Piercy R J, Garcia L, Amthor H
Proc Natl Acad Sci USA 120(2):e2206324120 -
Oligonucleotide Enhancing Compound Increases Tricyclo-DNA Mediated Exon-Skipping Efficacy in the Mdx Mouse Model
Bizot F, Fayssoil A, Gastaldi C, Irawan T, Phongsavanh X, Mansart A, Tensorer T, Brisebard E, Garcia L, Juliano R L, Goyenvalle A
Cells 12(5):702 -
Palmitic acid conjugation enhances potency of tricyclo-DNA splice switching oligonucleotides
Relizani K, Echevarria L, Zarrouki F, Gastaldi C, Dambrune C, Aupy P, Haeberli A, Komisarski M, Tensorer T, Larcher T, Svinartchouk F, Vaillend C, Garcia L, Goyenvalle A
nar Vol. 50, No. 1, 17–34 -
Partial Restoration of Brain Dystrophin and Behavioral Deficits by Exon Skipping in the Muscular Dystrophy X-Linked (mdx) Mouse
Zarrouki F, Relizani K, Bizot F, Tensorer T, Garcia L, Vaillend C, Goyenvalle A
Ana 92(2):213-229 -
Identifying and Avoiding tcDNA-ASO Sequence-Specific Toxicity for the Development of DMD Exon 51 Skipping Therapy
Aupy P, Echevarria L, Relizani K, Zarrouki F, Haeberli A, Komisarski M, Tensorer T, Jouvion G, Svinartchouk F, Garcia L, Goyenvalle A
Mol Ther Nucleic Acids 19: 371-383 -
Live-imaging of revertant and therapeutically restored dystrophin in the DmdEGFP-mdx mouse model for Duchenne muscular dystrophy
Petkova M V, Stantzou A, Morin A, Petrova O, Morales-Gonzalez S, Seifert F, Bellec-Dyevre J, Manoliu T, Goyenvalle A, Garcia L, Richard I, Laplace-Builhé C, Schuelke M, Amthor H
Neuropathology and Applied Neurobiology doi: 10.1111/nan.12639 -
Long-Term Efficacy of AAV9-U7snRNA-Mediated Exon 51 Skipping in mdx52 Mice
Aupy P, Zarrouki F, Sandro Q, Gastaldi C, Buclez P-O, Mamchaoui K, Garcia L, Vaillend C, Goyenvalle A
Molecular Therapy: Methods & Clinical Development 17: 1037-1047 -
Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington's Disease
Imbert M, Blandel F, Leumann C, Garcia L, Goyenvalle A
Nucleic Acid Ther 29(5): 256-265 -
BMP signaling regulates satellite cell-dependent postnatal muscle growth
Stantzou A, Schirwis E, Swist S, Alonso-Martin S, Polydorou I, Zarrouki F, Mouisel E, Beley C, Julien A, Le Grand F, Garcia L, Colnot C, Birchmeier C, Braun T, Schuelke M, Relaix F, Amthor H
Development 144(15): 2737-2747 -
Characterization of a Dmd (EGFP) reporter mouse as a tool to investigate dystrophin expression
Petkova M V, Morales-Gonzales S, Relizani K, Gill E, Seifert F, Radke J, Stenzel W, Garcia L, Amthor H, Schuelke M
Skelet Muscle 6(25) -
Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides
Goyenvalle A, Leumann C, Garcia L
J Neuromuscul Dis 3(2): 157-167 -
Dysferlin rescue by spliceosome-mediated pre-mRNA trans-splicing targeting introns harbouring weakly defined 3' splice sites
Philippi S, Lorain S, Beley C, Peccate C, Precigout G, Spuler S, Garcia L
Hum Mol Genet 24(14): 4049-4060 -
Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers
Goyenvalle A, Griffith G, Babbs A, Andaloussi S E, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Volt T, Amthor H, Buhr C, Schurch S, Wood M J A, Davies K E, Vaillend C, Leumann C, Garcia L
Nat Med 21(3): 270-275 -
In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis.
Bajanca F, Gonzalez-Perez V, Gillespie S J, Beley C, Garcia L, Theveneau E, Sear R P, Hughes S M
Elife 4: e06541 -
Un nouvel outil pour le traitement de la myopathie de Duchenne : les tricyclo-ADN
Goyenvalle A, Griffith G, Avril A, Amthor H, Garcia L
Med Sci (Paris) 31(3): 253-256 -
Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle
Mouisel E, Relizani K, Mille-Hamard L, Denis R, Hourde C, Agbulut O, Patel K, Arandel L, Morales-Gonzalez S, Vignaud A, Garcia L, Ferry A, Luquet S, Billat V, Ventura-Clapier R, Schuelke M, Amthor H
Am J Physiol Regul Integr Comp Physiol 307(4): R444-R454